Specific projects
Specific projects and products
Department’s products in the field of cellular immunotherapy:
- Production of allogeneic natural killer cells in the GMP system used in the treatment of cancer
- Production of dendritic cells in vitro
Specific products of the department in the field of reconstructive medicine:
- Embryonic membrane-derived mesenchymal cell production in the GMP system in the treatment of acute GVHD
Specific Projects
- Cellular immunotherapy:
Production, development and evaluation of dendritic tuberculosis cell vaccines in patients with triple negative breast cancer (laboratory study and phase one clinical trial)
Evaluation of safety and feasibility of NK cell haplotype infusion after in vitro culture in patients with metastatic and refractory breast cancer (phase one / two clinical trials)
Phase one and two clinical trials using amplified NK cells derived from hypoidentical individuals in Ex vivo to resistant and high-risk individuals with AML
Production and proliferation of cytokine-induced lethal immune cells (CIK) with good production conditions (GMP-grade) and phase one clinical therapy of cellular immunotherapy in patients with refractory metastatic breast cancer
Evaluation of the effects of pentoxifylline on the phenotype and antitumor function of tumor-infiltrated lymphocytes (TIL) in vitro and in a BALB / c mouse model with breast cancer (PhD student thesis)
Design, optimization and evaluation of exosomal formulations of paclitaxel and siRNA anti-stathmin combination on MDA-MB-231 PTX-resistant breast cancer cell line (MDA-MB-231 / PTX) (PhD student thesis)
Production of T cell product against BK virus for selective cell therapy in patients with refractory hemorrhagic cystitis after stem cell transplantation
Evaluation of safety and feasibilty of allogeneic NK cell infusion after culture in vitro in patients with acute respiratory distress syndrome resulting from COVID-19 (phase one / two clinical trial)
- Restorative medicine using mesenchymal cells
Comparison of phenotype and function of mesenchymal cells derived from adipose tissue, bone marrow and embryo and placental tissue in different passages (p2-p5-p10) (PhD student thesis)
Isolation, purification and commercialization of stem cells from the embryo and their characterization, their use for the treatment of patients with acute respiratory distress syndrome ARDS
Study of the effect of embryonic membrane-derived mesenchymal cells in the treatment of acute graft rejection (GVHD) (Phase 1 and 2 clinical trials) (PhD student thesis)
Commercialization of the treatment of refractory vitiligo using melanocytes and keratinocytes (general medical student thesis)
Evaluation of the effect of HLA compliance between DSC cells and responsive T cells on DSC immune modulation performance
Isolation, purification and characterization of exosomes extracted from human embryonic membrane-derived mesenchymal stem cells for the treatment of graft-versus-host disease (Translational Medicine)
Human placenta-derived mesenchymal stem cell transplantation in COVID-19 acute respiratory distress syndrome (phases one and two of clinical trials)