Institute C.V

visits:214

Major Ongoing Research Projects

Department of Advanced Therapy and Medicinal Products

Production, development and performance evaluation of tuberculosis dendritic cell vaccines in TNBC breast cancer patients (laboratory study and phase one clinical trial)
Evaluation of safety and feasibility of haplotype NK-cell infusion after cultivation in the
laboratory environment in patients with metastatic and resistant breast cancer (phase one/two clinical trial)
A phase one and two clinical trial using cloned NK cells derived from haploidentical individuals
In vivo Ex to treatment-resistant and high-risk AML patients
Production and expansion of cytokine-induced killer immune cells (CIK) with good production conditions (GMP grade) and a phase one clinical trial of cellular immunotherapy in patients with metastatic treatment-resistant breast cancer patients
Investigating the effects of pentoxifylline on the phenotype and antitumor function of lymphocytes infiltrating the tumor (TIL) in vitro and in the c/BALB mouse model with breast cancer)
Design, optimization and evaluation of paclitaxel and stathmin-anti siRNA combination exosomal formulation. MB-MDA231- breast cancer cells resistant to MB-MDA (PTX231-/PTX)
Production of T cell products against BK virus for selective cell therapy in cystitis patients
Treatment-resistant hemorrhagic after stem cell transplantation
Evaluation of safety and feasibility of allogeneic NK cell infusion after cultivation in the environment
laboratory in patients suffering from acute respiratory distress syndrome resulting from COVID-19 (phase one/two clinical trial)

Department of Clinical Researches

A comparative study of the results of vacuum sampling after neoadjuvant chemotherapy and surgical pathology in breast cancer patients in determining the amount of residual tumor
Contribution in the clinical phase of the microfluidic chip manufacturing project for the isolation of cancer cells in the peripheral circulation of breast cancer patients
Contribution in the clinical phase "Non-targeted examination of metabolome and analysis of plasma amino acids and fatty acids in breast cancer patients with and without complete pathological response after neoadjuvant chemotherapy and determination of molecular sub-groups characteristics and comparison with healthy individuals"
Examining the complete and relative pathological response after neoadjuvant chemotherapy and comparing related factors and survival of two groups
Investigating the risk factors of breast cancer in Iranian women by meta-analysis
Design and production of chemotherapy dose calculation software for breast cancer patients
Design and evaluation of decision support system for breast cancer patients
Evaluation of disease-free survival after vacuum biopsy of breast tumors as an adjuvant treatment at the same time as neoadjuvant treatment in elderly inoperable patients
Preparation of decellularized xenograft skin matrix and preparation of synthetic mesh for use in breast reconstruction surgery using implants
Compilation of an operational plan and implementation protocol to improve the well-being of women with breast cancer
Collaboration in the clinical trial phases of the project to identify novel autoantibodies associated with breast tumor through serological proteome analysis (SERDA) of placental proteins.
Cooperation in the clinical trial phases of the plan to investigate the possibility of early detection and predicting the prognosis of breast cancer from clinical trial blood samples
Examining the status of patients diagnosed with granulomatous mastitis referring to the specialized clinics of Motamed Research Institute in terms of the frequency of treatment methods and the results of response to treatment in a two-years period
Design and production of chemotherapy dose calculation software for breast cancer patients
Design and evaluation of decision support system for breast cancer patients (first phase) Design and evaluation of decision support system for breast cancer patients (second phase)
Collaboration in the clinical phase of designing and producing a 21-gene kit that determines the need for chemotherapy in breast cancer
Cooperation in the clinical trial phases of the plan to investigate the possibility of early detection and predicting the prognosis of breast cancer from clinical trial blood samples

Department of Cancer Genetics

Validation of polygenic risk score of breast cancer in Iranian women
Establishment of breast cancer specimen biobank
Launching a targeted precision oncology pipeline for determination of diagnosis, prognosis and treatment in cancer patients
12 genes kit (Mamonivap) for determining the need for Chemotherapy in breast cancer
21 genes kit for determining the need for chemotherapy in breast cancer (Oncotype recurrence score assay kit)
Membership and collaboration of Motamed Cancer Research Institute with CIMBA International Consortium